ABSTRACT
A well-designed assessment has beneficial impacts on students' learning and competency attainment. Failure in obtaining psychomotor learning competency, lack of understanding of assessment principles among instructors, unoptimized information and technology facilities, and difficulties in ensuring the integrity of online examination are among the threats to validity of online anatomy assessment during the COVID-19 pandemic. To ensure the validity of anatomy assessment during the pandemic, it is important to adopt several educational principles into the assessment design. We solidify the input discussed in the Malaysian Anatomical Association webinar 2021, on the challenges of anatomy online assessment and proposed six solutions to the challenges, namely adopting the programmatic assessment design, conducting small group in-person high stake examination, modifying assessment policy, utilizing question bank software, upgrading ICT facilities, and offering the ICT training to the students and instructors. It is envisioned that anatomy assessment are future ready are adaptive to change. © 2022 UPM Press. All rights reserved.
ABSTRACT
Under the circumstance of continuous variation of COVID-19 virus, verified the temporariness of the vaccines made by various countries. One cannot expect permanent protection by accepting only one dose of vaccine. In order to prepare and respond to the pandemic, many countries are applying different strategies to increase vaccination rates. The WHO appeals to the world to take the vaccine booster shot for community immunity. Relevant authorities then have to provide and spread visual health messages on the booster shot to keep the public informed. This study examine how unofficial organizations can guide and persuade people to adopt relevant health actions more effectively (such as continuous vaccination) by introducing emoji with different emotional valences in different message framing. An online experiment adopted a 2 (emoji: positive versus negative) × 2 (message framing: gain framing versus loss framing) design to investigate the effects of contrary emoji on people’s self-efficacy to continuously take the booster shot. In total of 240 university students were recruited to participate in this study. Within two types of message framing, the experiment simulated 4 pieces of health messages on the COVID-19 booster shot released by an unofficial organization, together with emoji of two emotional valences. The results showed that health messages with negative emoji result in stronger self-efficacy to user. Moreover, there is an interaction effect between emoji and message framing on self-efficacy. This study is intended to provide meaningful insights for health communicators, visual designers and health practitioners concerned. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
ABSTRACT
Background: DARA, a human anti-CD38 IgGκ monoclonal antibody, is approved in many countries as monotherapy in relapsed/refractory MM (RRMM) and in combination with standard of care (SoC) in RRMM and NDMM. However, no clinical studies have yet compared DARA maintenance versus SoC maintenance. The ongoing phase 3 AURIGA study will evaluate the addition of DARA to lenalidomide maintenance among pts with NDMM who are MRD positive after SoC induction and ASCT. The primary endpoint is the conversion rate to MRD negativity after 1 year of maintenance therapy. Methods: This openlabel, multi center, randomized phase 3 study will enroll approximately 214 pts in the United States aged 18-79 years with NDMM who receive ≥4 cycles of induction followed by ASCT. Pts must enroll within 6 months of ASCT, be naïve for anti-CD38 treatment, have a very good partial response or better per IMWG criteria, and be MRD positive at a threshold of 10-5 by next generation sequencing (NGS) within 30 days of screening. Pts will be stratified by cytogenetic risk (high vs standard/unknown) and randomized 1:1 to 28-day cycles of lenalidomide maintenance (10 mg PO;D1-28 [dose increasing to 15 mg if tolerated]) ± DARA SC (DARA 1,800 mg co-formulated with recombinant human hyaluronidase PH20 [rHuPH20;2,000 U/mL;ENHANZE®drug delivery technology, Halozyme, Inc., San Diego, CA, USA;QW Cycle 1-2, Q2W Cycles 3-6, Q4W C7+). Treatment will continue for up to 36 cycles or until disease progression, unacceptable toxicity, or patient withdrawal. The primary endpoint is MRD conversion rate after 12months of maintenance treatment, defined as the proportion of pts who achieve MRD negativity (10-5) by NGS. Additional MRD assessments occur after 18, 24, and 36 months of maintenance. While MRD negativity is associated with improved long-term outcomes for pts with MM and is an emerging, validated prognostic factor, this study is among the first to use MRD negativity as a primary study endpoint. Importantly, MRD negativity allows for earlier efficacy assessment than traditional endpoints such as progression-free survival (PFS) and overall survival (OS). Secondary endpoints include overall MRD conversion rate at any time, sustained MRD negativity lasting ≥12 months, PFS, OS, response rates, duration of complete response, changes in health-related quality of life, and safety. Due to the COVID-19 pandemic, this study has been amended to improve enrollment access by allowing up to 12 months from start of induction therapy to ASCT to mitigate against ASCT delays and to allow greater flexibility for screening and laboratory assessments.
ABSTRACT
The abrupt transition from face-to-face to online anatomy teaching amidst the COVID-19 pandemic has posed great challenges to anatomy lecturers in Malaysia, as they have had to adapt to new skills to prepare and deliver online classes. These online classes were delivered either synchronously via a web teleconferencing application or asynchronously through pre-recorded videos that were uploaded to the learning management system (LMS). The online delivery of anatomy practical classes has become a major concern among anatomy lecturers and students, especially in public institutions, as there is a lack of hands-on experience and social interaction. Nevertheless, some private medical schools have adapted well to both online lectures and practical classes, as they had been venturing towards online learning and virtual reality tools even before the pandemic commenced. The Malaysian Anatomical Association (MAA) webinar, "Transformation of Anatomy Education in Malaysia during COVID-19 Pandemic", discussed the issues related to lecturers' and students' receptivity to online anatomy classes. This study discusses the issues related to online anatomy teaching and learning (T&L) and the actions taken by the university's governance and anatomy faculty members to resolve the issues discussed in the academic discourse. © 2021 Malaysian Association of Education in Medicine and Health Sciences and Penerbit Universiti Sains Malaysia.